avartaki :

Phytochemistry:

The flower and leaf extract of CA is shown as antihyperglycemic in streptozotocin-induced experimental diabetes. Methanolic extracts of CA flowers have been demonstrated to inhibit α-glucosidase in vivo as well as in vitro. Its aqueous extract is reported to prevent the lipid peroxidation in brain of diabetic rats. Hyponidd, a formulation containing CA has been shown as antihyperglycemic and antioxidant. Polyphenols are considered to be the active ingredients of CA. Generally, hydro-alcoholic solvent is used to extract polyphenols from the crude herbal material. Traditional medicine practice also generally advocates use of hydro-alcoholic (HA) extracts of herbal materials. Yet, there is a growing practice to adopt technology-based supercritical fluid extracts (SFE) for higher yields of polyphenol and are now widely used by the industry. However, technology-based extracts such as SFE has no prior evidence of traditional use and hence we attempted a safety pharmacology study.

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