akarakarabha :

Precautions:

Although In large dose the powdered root is an irritant to the mucous membrane of the intestine causing blood stools, tetanus-like spasms and profound stupor , contact dermatitis if handled incorrectly

Toxicity studies:

Akarkara is very safe drug even taken in high doses. A study per OECD guidelines showed that different root extracts of Akarkara did not cause any apparent toxicity in animal models. No death or signs of toxicity were observed

in rats treated with extracts at dose 2000 mg/kg, establishing its safety.

LD50 value of Akarkara root extracts was found to be more than 2000 mg/kg of body weight. However, detailed experimental analysis of its chronic toxicity is essential for further support of this drug .