Although studies have shown no significant adverse side effects, 

Guduchi may be slightly constipating if taken for long periods by those prone to sluggish bowels. Guduchi can cause gastrointestinal upset when taken in large doses for long periods of time. Guduchi may lower blood glucose levels. Hnce people with Diabetes should take tthis herb only under medical supervision.

Its usage in pregnancy should be monitored under strict medical supervision