puga :
Research:
A study was designed to investigate the effect of hydroalcoholic extract of A. catechu L. nut (ANE) treatment on migraine pain in rat models to strengthen its use as an antimigraine therapy. The PPE was reduced in both ANE treated groups of rats. The percent fluorescein was significantly increased in positive control group (97.00+7%, P<0.0001) compared to negative control (63.87+1.2%). With ANE treatments (250 and 500 mg/kg.) PPE was significantly decreased to 88.88+1.4% (p<0.01) and 83.55+01%(p<0.0001) compared to positive control groups, respectively .
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