- Stem and bark yield alkaloids, flavonoids, glycosides, and tannins.

- An alcohol extract of bark yielded carbohydrates, alkaloids, phenols, tannins and phytosterols. A benzene extract yielded carbohydrates, flavonoids, and sterols.

- Leaves yield six major oxindolic alkaloids viz. mitraphylline, isomitraphylline, pteropodine, isopteropodine, speciophylline, and uncarine F. Other plant alkaloids are rotundifoline, rhynchophylline, isorotundifoline, rhynchociline, speciocilitine, speciofoline, mitragynine. Plant also yield compounds like pyroligneous acids, aldehydes, ketones, scopoletin, thermophylline, daucosterol, quinovic acid, ß-sitosterol and methyl acetate. 

- Leaves yielded four hetero-yohimbine type oxindole alkaloids from an acid base treated chloroform fraction of ethanolic extract of leaves:  17-dihydro-17b-hydroxy isomitraphylline , 17- dihydro-17b-hydroxy mitraphylline , together with two known alkaloids, isomitraphylline  and mitraphylline . Mitraphylline was the main alkaloid